Lee J. Martin, Ph.D.

Neuropathology Core: Co-Investigator
Associated Investigator
E-mail: martinl@jhmi.edu

Dr. Martin’s major research interest is cell death signaling in neurological disease. He uses animal and cell models of human neurodegenerative disease and the techniques of molecular neuropathology / neurobiology to unravel the mechanisms of neurodegneration.

Publications

• Kageyama Y, Saito A, Pletnikova O, Rudow GL, Irie Y, An Y, Murakami K, Irie K, Resnick SM, Fowler DR, Martin LJ, Troncoso JC. Amyloid beta toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques. Sci Rep. 2018; 8:16895
• Martin LJ, Chang Q. DNA damage response and repair: DNA methylation and cell death in human neurons and experimental animal neurons are different. J Neuropathol Exp Neurol 2018; 77: 636-655.
• Martin LJ, Wong M. Enforced DNA repair enzymes rescue neurons from apoptosis induced by target deprivation and axotomy in mouse models of neurodegeneration. Mech Ageing Dev 2017; 161: 149-162.
• LaClair K, Donde A, Ling J, Jeong Y, Chhabra R, Martin LJ, Wong PC. Depletion of TDP-43 decreases fibril and plaque B-amyloid and exacerbates neurodegeneration in an Alzheimer’s mouse model. Acta Neuropathol 2016; 132: 859-873.