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Gwenn Smith, Ph.D.

Associated Investigator
E-mail: gwsmith95@jhmi.edu

Dr. Smith’s research is primarily focused on using functional imaging, particularly positron emission tomography (PET), to understand the regulation of monoamine systems in the pathophysiology and treatment response in affective and cognitive disorders. She is currently examining the role of monoamine dysregulation in geriatric depression and Alzheimer’s disease.


  • Stevens DA, Workman CI, Kuwabara H, Butters MA, Savonenko A, Nassery N, Gould N, Kraut M, Joo JH, Kilgore J, Kamath V, Holt DP, Dannals RF, Nandi A, Onyike CU, Smith GS. Regional amyloid correlates of cognitive performance in ageing and mild cognitive impairment. Brain Commun. 2022;4:fcac016.
  • Oeltzschner G, Wijtenburg S, Mikkelsen M, Edden R, Barker P, Joo J, Leoutsakos J, Rowland L, Workman C, Smith GS. Neurometabolites and associations with cognitive deficits in mild cognitive impairment: A magnetic resonance spectroscopy study at 7 Tesla. Neurobiol Aging 2019; 73: 211-218.
  • Smith GS, Barrett F, Joo J, Nassery N, Savonenko A, Sodums D, Marano C, Munro C, Brandt J, Kraut M, Zhou Y, Wong D, Workman C. Molecular imaging of serontonin degeneration in mild cognitive impairment. Neurobiol Dis 2017; 105: 33-41.
  • Hirao K, Pontone GM, Smith GS. Molecular imaging of neuropsychiatric symptoms in Alzheimer’s and Parkinson’s disease. Neurosci Biobehav Rev 2014; 49C: 157-170.
  • Marano C, Workman C, Kramer E, Hermann C, Ma Y, Dhawan V, Chaly T, Eidelberg D, Smith G. Longitudinal studies of cerebral glucose metabolism in late-life depression and normal aging. Int J Geriatr Psychiatry 2013; 28: 417-423.


Primary Appointment in Psychiatry and Behavioral Science