Juan Troncoso, M.D.

Neuropathology Core Leader
E-mail: [email protected]

Dr. Troncoso is Professor of Pathology and Director of the Brain Resource Center at Johns Hopkins University School of Medicine. His research interests focus on the neuropathology of normal aging and the pathology, pathogenesis and therapy of neurodegenerative disorders. His research encompasses clinical-pathological correlations, morphological studies using unbiased stereology, and investigations of the pathogenesis of neurodegenerative disorders in relevant genetically-engineered mouse models and in vitro systems.

Publications

• Wingo AP, Liu Y, Gerasimov ES, Vattathil SM, Liu J, Cutler DJ, Epstein MP, Blokland GAM, Thambisetty M, Troncoso JC, Duong DM, Bennett DA, Levey AI, Seyfried NT, Wingo TS. Sex differences in brain protein expression and disease. Nat Med. 2023; 29:2224-2232.
• Martinez P, Patel H, You Y, Jury N, Perkins A, Lee-Gosselin A, Taylor X, You Y, Viana Di Prisco G, Huang X, Dutta S, Wijeratne AB, Redding-Ochoa J, Shahid SS, Codocedo JF, Min S, Landreth GE, Mosley AL, Wu YC, McKinzie DL, Rochet JC, Zhang J, Atwood BK, Troncoso J, Lasagna-Reeves CA. Bassoon contributes to tau-seed propagation and neurotoxicity. Nat Neurosci. 2022; 25:1597-1607.
• Kageyama Y, Saito A, Pletnikova O, Rudow G, Irie Y, An Y, Murakami K, Irie K, Resnick S, Fowler D, Martin L, Troncoso J. Amyloid beta toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques. Sci Rep 2018; 8: 16895.
• Pletnikova O, Kageyama Y, Rudow GL, LaClair K, Albert M, Crain B, Tian J, Fowler D, Troncoso J. The spectrum of preclinical Alzheimer’s pathology and its modulation by ApoE genotype. Neurobiol Aging 2018; 71: 72-80.

Appointments

Primary Appointment in Pathology
Secondary Appointment in Neurology