Johns Hopkins Medicine

Alzheimer's Disease Research Center

Gwenn Smith, Ph.D.

Associated Investigator

Dr. Smith's research is primarily focused on using functional imaging, particularly positron emission tomography (PET), to understand the regulation of monoamine systems in the pathophysiology and treatment response in affective and cognitive disorders. She is currently examining the role of monoamine dysregulation in geriatric depression and Alzheimer's disease.


  • Smith GS, Barrett F, Joo J, Nassery N, Savonenko A, Sodums D, Marano C, Munro C, Brandt J, Kraut M, Zhou Y, Wong D, Workman C. Molecular imaging of serontonin degeneration in mild cognitive impairment. Neurobiol Dis 2017; 105: 33-41.
  • Lozano AM, Fosdick L, Chakravarty MM, Leoutsakos JM, Munro C, Oh E, Drake KE, Lyman CH, Rosenberg PB, Anderson WS, Tang-Wai DF, Pendergrass JC, Salloway S, Asaad WF, Ponce FA, Burke A, Sabbagh M, Wolk DA, Baltuch G, Okun MS, Foote KD, McAndrews MP, Giacobbe P, Targum SD, Lyketsos CG, Smith GS. A Phase II study of fornix deep brain stimulation in mild Alzheimer's disease. J Alzheimers Dis 2016; 54: 777-787.
  • Hirao K, Pontone GM, Smith GS. Molecular imaging of neuropsychiatric symptoms in Alzheimer's and Parkinson's disease. Neurosci Biobehav Rev 2014; 49C: 157-170.
  • Marano C, Workman C, Kramer E, Hermann C, Ma Y, Dhawan V, Chaly T, Eidelberg D, Smith G. Longitudinal studies of cerebral glucose metabolism in late-life depression and normal aging. Int J Geriatr Psychiatry 2013; 28: 417-423.


Primary Appointment in Psychiatry and Behavioral Science