Johns Hopkins Medicine

Alzheimer's Disease Research Center

Alena Savonenko, M.D., Ph.D.

Dr. Savonenko Photo

Associated Investigator

Dr. Savonenko's research interests include: neurobiological mechanisms of learning and memory, animal behavioral models, and neurobiological mechanisms of normal aging and neurodegenerative disorders, such as Alzheimer's disease.


  • Smith-Hicks C, Cai P, Savonenko A, Reeves R, Worley P. Increased sparsity of hippocampal CA1 neuronal ensembles in a mouse model of Down syndrome assayed by Arc expression. Font Neural Circuits 2017; 11: 6.
  • Savonenko A, Melnikova T, Wang Y, Ravert H, Gao Y, Koppel J, Lee D, Pletnikova O, Cho E, Sayyida N, Hiatt A, Troncoso J, Davies P, Dannals R, Pomper M, Horti A. Cannabinoid CB2 receptors in mouse model of Abeta amyloidosis: Immunohistochemical analysis and suitability as a PET biomarker of neuroinflammation. PLos One 2015; 18: e0129618.
  • LaClair KD, Manaye KF, Lee DL, Allard JS, Savonenko AV, Troncoso JC, Wong PC. Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice. Mol Neurodegener 2013; 8: 18.
  • Melnikova T, Fromholt S, Kim H, Lee D, Xu G, Price A, Moore B, Golde T, Felsenstein K, Savonenko A. Borchelt D. Reversible pathologic and cognitive phenotypes in an inducible model of Alzheimer-amyloidosis. J Neurosci 2013; 33: 3765-3779.


Primary Appointment in Pathology