Johns Hopkins Medicine

Alzheimer's Disease Research Center

Resources for Researchers

The Johns Hopkins ADRC provides researchers with various research-related resources. These include access to participants, data, MRI images and biospecimens from well-characterized subjects who fall into the following categories: normal controls, individuals with mild memory problems, and patients diagnosed with dementia due to Alzheimer's disease and related disorders.


Access research participants from the ADRC's Memory & Aging Study

The ADRC Clinical Core follows approximately 500 participants longitudinally with a range of clinical diagnoses, as described above. Participants are evaluated annually with standardized clinical and cognitive assessments. Qualified investigators at Johns Hopkins University, with IRB approved studies, may request access to these participants for their research. A Subject Request Form should be submitted to Carol Gogel, RN, the Clinical Coordinator for the ADRC. Ms. Gogel can also answer any questions you may have about these participants.


MRI brain imaging data and images from ADRC participants

The ADRC Biomarker Core acquires MRI brain scans from participants enrolled in the ADRC who have a range of clinical diagnoses, as described above. The MRI scans include the following sequences: MPRAGE, FLAIR, DTI, rs-fMRI and QSM. These images are processed through standard pipelines. Qualified investigators may request these brain images, as well as the imaging data derived from them, for their research. An MRI Request Form should be submitted to Kylie Alm, PhD. Dr. Alm can also answer any questions you may have about the brain images and the brain imaging data available.


Biospecimens collected from ADRC participants

The ADRC Biomarker Core acquires blood and cerebrospinal fluid (CSF) specimens from participants enrolled in the ADRC who have a range of clinical diagnoses, as described above. The blood specimens include plasma, serum and buffy coat. These blood and CSF specimens are frozen for future use. Qualified investigators may request these biospecimens for their research. A Specimen Request Form should be submitted to Abhay Moghekar. Dr. Moghekar can also answer any questions you may have about these biospecimens.


Brain specimens collected from ADRC participants

The ADRC Neuropathology Core acquires autopsy tissue from ADRC participants who have been followed longitudinally through the Clinical Core. These participants have a range of clinical diagnoses, as described above. Standard brain tissue sections are fixed in formalin or frozen for future use. Qualified investigators may request these brain tissue specimens for their research. A Brain Tissue Request Form should be submitted to Javier Redding, MD. Dr. Redding can also answer any questions you may have about these brain tissue specimens.


Data from ADRC participants

Data from the ADRC participants described above, as well as neuropathological findings based on autopsy tissue from these participants, are available for analysis through the ADRC Data Management and Biostatistics Core. Qualified investigators may request these data for their research. A Data Request Form should be submitted to Kylie Alm, PhD. Dr. Alm serves as the ARDC Data Navigator and can answer any questions you may have about these data. Additionally, she can help investigators design the details of their data request.


Biostatistical support for researchers affiliated with the ADRC

Researchers who have projects affiliated with the ADRC can request statistical consultation and support from the ADRC Data Management and Biostatistics Core. This includes investigators leading ADRC Developmental Projects and Scholars supported through the Research Education Component. This includes assistance with study design, power calculations and data analysis. A Biostatistical Request Form should be submitted to Alden Gross, PhD. Dr. Gross can also answer any questions you may have about these services.