Johns Hopkins Medicine

Alzheimer's Disease Research Center

Resources for Researchers

The Johns Hopkins ADRC provides researchers with access to various research-related resources. These include access to participants, data, MRI images and biospecimens from well-characterized individuals who fall into the following groups: normal controls, individuals with mild memory problems, and patients diagnosed with dementia due to Alzheimer's disease or related disorders, as described below.


Access research participants from the ADRC's Memory & Aging Study

Researchers affiliated with the Johns Hopkins ADRC have the opportunity to recruit well-characterized participants from the ADRC's longitudinal Memory & Aging Study into their clinical research studies. Access to these subjects can be provided to investigators associated with the ADRC, with IRB approved projects related to AD and related disorders. To obtain approval, a Subject Request Form should be submitted to the Clinic Coordinator of the ADRC (Carol Gogel, RN), who can also provide information about the characteristics of the subjects available and the procedures for contacting them, once the request is approved. The completed form should be submitted to Carol Gogel and will then be reviewed by the ADRC Executive Committee.


MRI brain imaging data and images from ADRC participants

Data derived from MRI brain images, as well as raw MRI brain images, can be provided to investigators associated with the ADRC who also have IRB approval to analyze these data and/or images. To obtain approval, an MRI Request Form should be submitted to the Biomarker Core Coordinator (Carrie Wagandt), who can also provide information about the types of MRI sequences that have been collected and the processed data that are available. The completed form should be submitted to Carrie Wagandt and will then be reviewed by the ADRC Executive Committee.


Biospecimens collected from ADRC participants

Blood specimens, DNA and CSF collected from ADRC participants: Blood specimens, DNA and CSF can be provided to investigators associated with the ADRC who also have IRB approval to analyze these specimens. To obtain approval, a Specimen Request Form should be submitted to the Biospecimen Coordinator, Jackie Darrow, who can also provide information about the types and volume of specimens that are available. The completed form should be submitted to Jackie Darrow and will then be reviewed by the ADRC Executive Committee.


Brain specimens collected from ADRC participants

Brain specimens can be provided to investigators whose research requires brain tissue from well-characterized individuals across the AD spectrum. To obtain approval, a Brain Tissue Request Form should be submitted to the BRC Manager (Olga Pletnikova). She can also provide information summarizing the types of brain specimens that are available. The completed form should be submitted to Olga Pletnikova and will then be reviewed by the ADRC Executive Committee.


Data from ADRC participants

Cross-sectional or longitudinal clinical and cognitive data files can be provided to investigators associated with the ADRC. To obtain approval, a Data Request Form should be submitted to a member of the ADRC Data Management and Biostatistics Core (Jing Tian), who can also provide information about the contents of the data files. The completed form should be submitted to Jing Tian and will then be reviewed by the ADRC Executive Committee.


Biostatistical support for researchers affiliated with the ADRC

Researchers who have projects associated with the ADRC can request statistical consultation and support through the ADRC Data Management and Biostatistics Core. This includes investigators leading ADRC Developmental Projects and fellows supported through the Research Education Component. This support includes assistance with: study design, the development of analytic plans, power calculations and data analysis. To obtain approval, a Biostatistics Request Form should be submitted to a member of the Data Management and Biostatistics Core (Alden Gross), who can also provide details about the type of support that is available. The completed form should be submitted to Alden Gross and will then be reviewed by the ADRC Executive Committee.