Johns Hopkins Medicine

Alzheimer's Disease Research Center

Developing New Animal Models for AD

Principal Investigators: Philip Wong, Ph.D. and Tong Li, Ph.D.

The goal of this project is to characterize a recently developed mouse model that not only exhibits amyloid β (Αβ) amyloidosis and tauopathy, but also displays robust age-dependent neuronal loss. This new mouse model will be used to test the overarching hypothesis that Αβ induces tau aggregation, which in turn initiates synaptic dysfunction and promotes neuronal loss. The research team hopes is that such a model system will provide the opportunity to evaluate Αβ amyloidosis and tauopathy dependent loss of neurons as the principal outcome measure in preclinical testing of mechanism-based therapies, such as those designed to target tauopathy and/or Αβ amyloidosis.

For more information please contact Dr. Philip Wong at 443-287-5689.