Johns Hopkins Medicine

Alzheimer's Disease Research Center

ADRC Longitudinal Evaluation

Principal Investigator: Constantine Lyketsos, M.D.

The Memory & Aging Study

The Memory & Aging Study of the Johns Hopkins Alzheimer's Disease Research Center is an ongoing study that is designed to learn more about the differences between normal aging, mild memory problems, and memory disorders, such as Alzheimer's Disease.

Annual Evaluation and Follow-up

The Center enrolls a variety of individuals for evaluation and follow-up, including:

  • persons without memory or other cognitive problems,
  • individuals with mild memory problems, and
  • patients with a diagnosis of dementia due to Alzheimer's Disease or related disorder.

Participants are evaluated annually. An individual who knows the participant well must also be available to contribute information annually. These evaluations are given in a standard manner so that new information about diagnosis and treatment can be obtained. We are currently focusing on the very earliest stages of disease.

More details about the Memory & Aging Study can be found in the study brochure.

Annual Evaluation

Dr. Lee Participants are seen once a year. To participate, you must have a study partner (a spouse, family member or close friend) who can provide information on how you are functioning in daily life. The annual exam takes approximately 2-3 hours. The visit includes: an interview to obtain information about your daily function, brief medical, neurologic and psychiatric evaluations, and tests of mental ability (such as memory). Additionally, blood is drawn to examine potential markers related to memory loss. You may also be asked to participate in other procedures that provide insight into changes that might be occurring in your brain. These include the collection of:

(1) Magnetic Resonance Imaging (MRI) scans for providing information about the structure and function of your brain, and
(2) the collection of cerebrospinal fluid (CSF), using a procedure known as a lumbar puncture (LP), for providing information about alternations in levels of proteins, fats and other substances in the brain.

Anatomical and biochemical study of the brain after death is also important in helping us understand more about disorders such as Alzheimer's disease. A staff member will discuss brain autopsy options with you.

Other clinical studies conducted in association with the Center will be described to you, including:

  • studies that examine how individuals think and organize information,
  • studies that use brain imaging,
  • intervention studies/clinical trials involving lifestyle factors or medications that seek to delay or treat symptoms of dementia, and
  • studies about genetic factors that influence the development AD.

For more information regarding this study, please contact Carol Gogel, RN at 410-550-9029 or