Johns Hopkins Medicine

Alzheimer's Disease Research Center

ADRC Longitudinal Evaluation

Principal Investigator: Constantine Lyketsos, M.D.

Annual Evaluation and Follow-up

The Center enrolls a variety of individuals for evaluation and follow-up, including:

  • individuals with mild memory problems,
  • patients with a diagnosis of Alzheimer's Disease or a related dementia, and
  • persons without memory or other cognitive problems (to serve as control participants).

Participants are evaluated annually. An individual who knows the participant well must also be available to contribute information annually. These evaluations are given in a standard manner so that new information about diagnosis and treatment can be obtained. We are currently focusing on the very earliest stages of disease.

Annual Evaluation

Dr. Lee Participants are seen once a year for a thorough evaluation. To participate, you must have a study partner (a spouse, family member or close friend) who can comment on your daily activities. The annual exam takes approximately 3-4 hours. At each visit an interview is conducted to evaluate your function in daily life. Brief medical, neurologic and psychiatric evaluations are completed, and tests of mental ability (such as memory) are given. At each exam, blood is drawn to examine genetic biomarkers that may be associated with memory problems.

Anatomical and biochemical study of the brain after death is also important in helping us understand more about disorders such as Alzheimer's disease. A staff member will discuss brain autopsy options with you.

Other clinical studies conducted in association with the Center will be described to you, including:

  • clinical trials of medications that seek to delay or treat symptoms of dementia,
  • studies that examine how individuals think and organize information,
  • studies that use brain imaging, and
  • studies about genetic factors that influence the development AD.

For more information regarding this study, please contact Carol Gogel, RN at 410-550-9029 or