Johns Hopkins Medicine

Alzheimer's Disease Research Center

Developing New Animal Models for AD

Principal Investigator: Philip Wong, Ph.D.

The goal of this study is to characterize a new mouse model of Alzheimer's disease that combines several of the co-occurring pathological features of the disease. These features include deposition of amyloid plaques, phosphorylated tau tangles and aggregates of TDP-43. One of the important features of this mouse model is that it demonstrates age-related neuron loss. A comprehensive set of molecular, pathological, neuronal circuit and behavioral/cognitive analyses are underway, in order to gain a fuller understanding of this model, so that is may be possible to use it to examine novel therapeutic approaches for AD.

For more information please contact Dr. Philip Wong at