Johns Hopkins Medicine

Alzheimer's Disease Research Center

Developing New Animal Models for AD

Principal Investigator: Philip Wong, Ph.D.

The goal of this study is to characterize a new mouse model of Alzheimer's disease that combines several of the co-occurring pathological features of the disease. These features include deposition of amyloid plaques, phosphorylated tau tangles and aggregates of TDP-43. One of the important features of this mouse model is that it demonstrates age-related neuron loss. A comprehensive set of molecular, pathological, neuronal circuit and behavioral/cognitive analyses are underway, in order to gain a fuller understanding of this model, so that is may be possible to use it to examine novel therapeutic approaches for AD.

For more information please contact Dr. Philip Wong at wong@jhmi.edu.