Johns Hopkins Medicine

Alzheimer's Disease Research Center

Brain Protein Alterations in Alzheimer's Disease

Principal Investigator: Paul Worley, M.D.

This research program is examining a range of brain proteins that appear to be altered during the early phase of Alzheimer's disease. This includes NPTX2, which mediates adaptive control of excitation/inhibition in brain circuits, mTORC1, which integrates cellular metabolism and controls processes including protein translation, mitochondrial function, and autophagy, and GDE2, which controls signaling mediated through the extracellular matrix and provides an index of cellular redox dynamics.

For more information please contact Dr. Paul Worley at