Johns Hopkins Medicine

Alzheimer's Disease Research Center

Impact of Abeta on Synaptic Plasticity

Principal Investigator: Richard Huganir, PhD

This project is focused on the regulation of α-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptors (AMPARs) by amyloid β (Aβ). The goal is to identify mechanisms by which Aβ alters synaptic transmission and plasticity during the early stages of Alzheimer's disease (AD), prior to cell death. AMPARs mediate the majority of fast excitatory neurotransmission in the central nervous system and are dynamically regulated by modifications, such as phosphorylation, and by interactions with other proteins. This regulation of AMPARs is critical for modulating synaptic transmission and plasticity. This research team is seeking to determine whether Aβ induces synaptic deficits by interfering with the normal regulation of AMPARs, resulting in down-regulation of AMPARs at excitatory synapses.

For more information please contact Dr. Richard Huganir at 410-955-4050.